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Semaglutide

Rx only

Part of Weight Loss & Metabolic The most-searched category on the platform

Clinical dosing reference — FDA-approved only

Shown only for prescription drugs with an FDA label. This describes how these medications are typically prescribed, not a recommendation for you specifically — your prescriber sets and adjusts your actual dose.

Semaglutide (Wegovy)

Titration
Weekly subcutaneous injection, starting at 0.25 mg. Dose is increased roughly every 4 weeks — 0.25 mg → 0.5 mg → 1 mg → 1.7 mg → 2.4 mg — over about 16 weeks, to reduce GI side effects.
Maintenance dose
2.4 mg once weekly (1.7 mg is an FDA-approved alternative maintenance dose for patients who don't tolerate 2.4 mg).
Trial results
In the STEP 1 trial (68 weeks), participants on semaglutide plus lifestyle intervention lost a mean of 14.9% of body weight, vs. 2.4% on placebo.
Source: FDA prescribing information (DailyMed)

Other compounds in this category have no FDA-approved human dosing to cite — see the note below.

Recent research

Live results from PubMed, the NIH’s public database of biomedical literature.

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Semaglutide is an FDA-approved prescription therapeutic available only through a licensed provider. This page does not recommend or endorse use outside of professional medical guidance. See the full disclaimer.
Semaglutide — Peptide Guide | A Peptide Store